Depressive illness delayed Hamlet's revenge.

Current irritability associated with hastened depressive recurrence and delayed depressive recovery in bipolar disorder

BACKGROUND Current irritability is associated with greater retrospective and current bipolar disorder (BD) illness severity; less is known about prospective longitudinal implications of current irritability. We examined relationships between current irritability and depressive recurrence and recovery in BD. METHODS Outpatients referred to the Stanford BD Clinic during 2000-2011 were assessed ...

A Unifying Mechanism for Cancer Cell Death through Ion Channel Activation by HAMLET

Ion channels and ion fluxes control many aspects of tissue homeostasis. During oncogenic transformation, critical ion channel functions may be perturbed but conserved tumor specific ion fluxes remain to be defined. Here we used the tumoricidal protein-lipid complex HAMLET as a probe to identify ion fluxes involved in tumor cell death. We show that HAMLET activates a non-selective cation current...

Excerpts from Ernest Jones’ Essay: THE OEDIPUS-COMPLEX AS AN EXPLANATION OF HAMLET'S MYSTERY: A STUDY IN MOTIVE

Hamlet's "Globe" and the Self as Performer in England and Japan

In his paper, "Hamlet's 'Globe' and the Self as Performer in England and Japan," Yu Shibuya argues that Hamlet sees his life as a performance. Shibuya presents examples from Tsuneari Fukuda's Japanese translation to suggest that Fukuda makes choices that emphasize the theatrical side of Hamlet's character. If Hamlet perceives himself as an actor, then his definition of theater or an actor is ul...

Blunted response to feedback information in depressive illness.

Depressive illness is associated with sustained widespread cognitive deficits, in addition to repeated experience of distressing emotions. An accepted theory, which broadly accounts for features of the syndrome, and its delayed response to antidepressant medication, is lacking. One possibility, which has received considerable attention, is that depressive illness is associated with a specific u...